32 research outputs found

    UAS Literary & Arts Journal

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    Proof copy provided by Tidal Echoes.Tidal Echoes is an annual showcase of writers and artists with one thing in common: a life surrounded by the rainforests and waterways of Southeast Alaska.Davy Josh’s Note -- A Note from Chalise -- A Note from Emily Wall -- Brain Bucket -- Cephalic index -- A Gift of Fat for the Fire -- Our heroes have always been... -- Colorful Clouds -- Role Model -- Anchors -- Out My Window -- Adaptation -- Bookshelves -- In the Flow -- It’s a Small World Parade Float -- Sexy -- Death by Algebra -- Friend -- mirabile visu -- Exchange II -- F A D E -- Borne Alone -- Continuum -- The Week Before St. Valentine’s -- Bottled Up -- Untitled -- Early Morning Conspiracy Theory -- Westport -- Boulder Creek -- Jumping Off Rooftops -- Staying in the Room With Ernestine Hayes -- Blueberry -- After Neruda By Way of Bly (Tenure) -- Magic of Water -- Old Tom Steals the Light -- Old Tom Finds a Whale -- Research Project -- Guppy (boat) -- Arizona Spyder -- From Anthropomorphism to Zoomorphism -- Bus Stop -- December 1, 1955 -- Between Tides at Twilight -- Dementia -- Winter Ferry -- Coming into Auke Bay -- The Search for Jane Rogers -- Inlaid Tea Cups -- The Big Melt -- Kingsmill Reef -- Despite Man’s Best Efforts to Ruin It -- Roberts from Flume -- India Scarf -- Painted and Petrified -- Medicine Bag -- Merrill Field -- Deadly Kites -- Brazilian Ghetto -- Seattle Riff -- The Gospel Truth of My Gay Bird -- Signing the Divorce Papers -- Red Shades -- Holey Cow -- Untitled -- Series of Cedar Baskets -- A Conversation With Ranunculus -- Deconstruction -- Sandy Beach -- Threshold -- Oil and Honesty: An Interview with Artist and Professor David Woodie -- Mitkof #3 -- Still Life -- First Day of Fall -- Falling in the Garden -- After Finishing an Activities Report for the Dean -- Homage to Po Chü-I -- Nunc Dimittis -- Do Wise Men Have Bad Days? -- To the Plain Land -- Flood of ‘69 -- How a woman makes her own wine -- Untitled (translation from Russian) -- Existential Sestina -- It’s the knowing -- Blood and Guts -- Sometime Walking on the Beach -- Untitled -- Connecting the Pieces -- Hemlock -- Klawock Island -- Driven By the Tides -- Lunch -- The People -- Howling Dog -- Winter Cabin Lullaby -- Chain Gang -- A Review of Social Groups in Female Homo Sapiens as Exemplified by Mammary Restraint -- Apparatuses -- Douglas Island Bridge -- Going Home -- Author and Artist Biographie

    Alzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals

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    Background: Both Alzheimer’s disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR index score modifies the relationship between AD genetic risk factors and long-term cognitive trajectories in a large sample of individuals with normal cognition. Methods: Analyses used data from the Preclinical AD Consortium, including harmonized data from 5 longitudinal cohort studies. Participants were cognitively normal at baseline (M baseline age = 64 years, 59% female) and underwent 10 years of follow-up, on average. AD genetic risk was measured by (i) apolipoprotein-E (APOE) genetic status (APOE-ε2 and APOE-ε4 vs. APOE-ε3; N = 1819) and (ii) AD polygenic risk scores (AD-PRS; N = 1175). A CR index was calculated by combining years of education and literacy scores. Longitudinal cognitive performance was measured by harmonized factor scores for global cognition, episodic memory, and executive function. Results: In mixed-effects models, higher CR index scores were associated with better baseline cognitive performance for all cognitive outcomes. APOE-ε4 genotype and AD-PRS that included the APOE region (AD-PRSAPOE) were associated with declines in all cognitive domains, whereas AD-PRS that excluded the APOE region (AD-PRSw/oAPOE) was associated with declines in executive function and global cognition, but not memory. There were significant 3-way CR index score × APOE-ε4 × time interactions for the global (p = 0.04, effect size = 0.16) and memory scores (p = 0.01, effect size = 0.22), indicating the negative effect of APOE-ε4 genotype on global and episodic memory score change was attenuated among individuals with higher CR index scores. In contrast, levels of CR did not attenuate APOE-ε4-related declines in executive function or declines associated with higher AD-PRS. APOE-ε2 genotype was unrelated to cognition. Conclusions: These results suggest that APOE-ε4 and non-APOE-ε4 AD polygenic risk are independently associated with global cognitive and executive function declines among individuals with normal cognition at baseline, but only APOE-ε4 is associated with declines in episodic memory. Importantly, higher levels of CR may mitigate APOE-ε4-related declines in some cognitive domains. Future research is needed to address study limitations, including generalizability due to cohort demographic characteristics

    UAS Literary & Arts Journal

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    Proof copy provided by Tidal Echoes.Tidal Echoes presents an annual showcase of writers and artists who share one thing in common: a life surrounded by the rainforests and waterways of Southeast Alaska.A Note from Chalise Fisk -- A Note from Kaleigh Lambert -- A Note from Emily Wall -- A Note from Katie Spielberger -- The Sacred and the Profane -- Wild Polaroid -- Reflecting on the Old Dock on Auke Lake -- Dating Myself Forwarding John Updike's "Baseball" on The Writer's Almanac, June 22, 2009 -- Thoughts after Working on Salmon Eggs from our Grandson -- Burnt the Tea -- I Was in Love with a Boy Who Loved Dog-Sledding -- The Last Word -- Salmon Woman -- Organ Donor -- At First Sight -- The Dichotomy of Dog Salmon -- Winter in Lingit Aani Brings Magpies and Ravens -- To My Father, After My Last Summer Crewing on the Katrina Louise -- Damp -- Art 105 -- Portrait of a Man -- An Interview with Jane Terzis, Featured Artist -- I Have the Capacity for Patience -- 4-H -- Wildthing at the Glacier -- I Have the Capacity for Honesty -- I Have the Capacity for Obsessive Neatness -- I Have the Capacity for Stubbornness -- I Have the Capacity for Meanness -- I Have the Capacity to Kill -- Zora’s -- Thursdays after dinner -- Nixon’s reelection day -- They Break Not His Legs -- The girl -- How a mother remembers -- Atonement -- Earthbound -- Romance in the Newsprint (strangely devised personal ads) -- Memories of Winter -- Metamorphosis -- Rivers in Washington -- Light at the End of the Tunnel -- Sisters’ Islands -- Distress Signal -- Ice Caves and a Warm Wind -- Coke Train -- My Backyard’s Winter Anatomy -- Sunny With Chance of Feathers | Milky Way -- Tag -- Islands -- Such Great Heights -- The Seaweed Holt -- Sockeye -- Insider/Outsider | Little Bitch -- Pinocchio | Taylor, Home Depot, Tampa, 2001 -- Danielle and Zouzou -- My Father | Nine-Year-Old Kid -- A Little Bit of Everything: Interview with Nick Jans, Featured Writer -- Crossing Sawyer -- Summer’s Drift -- Waterline -- Ghost Meat, from the novel in process Nakolik -- The Giant’s Hand -- Rain Country -- The Stone Kyrielle -- Autograph -- Shards -- In Her Yellow Docs, She Shines -- Claudius Maximus -- Tracing Constellations -- Chasing the Promised Land -- My Favorite Story About Elizabeth -- The Destruction of the Russian Fort at New Archangel -- Jack of Hearts -- Beached -- Autumn Reflection -- JoJo | Guardian | King of the Jungle -- Child in the Woods -- Respite -- Burial at Sea -- Gold -- Geared for Drinking -- First Contact -- Fish Story -- Winter Mornings -- Downpour -- Feather -- Snowbirds -- The Sushi Chef Takes his Break During a Snowstorm on Lincoln Street -- Author and Artist Biographies -- Wash Day in Cobh, Ireland -- Alaska Fisherman’s Building -- Bleed -- Auke Lake Tre
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